Functional gene network visualization used in Boyle et al. 2018, Molecular Systems Biology
Browse online here
Visualize 1,528,726 co-essential genetic interactions among 17,634 genes (0.98% of all possible pairs)
See how to make figures similar to panels 4B-C, 5F, 6C-D, EV2, EV5C from my paper: https://www.embopress.org/doi/full/10.15252/msb.20188594
This work informed future development of the Broad Cancer DepMap gene dependency resource.
See some citing work below (message me if you'd like to be added to the list!):
- Extracting Biological Insights from the Project Achilles Genome-Scale CRISPR Screens in Cancer Cell Lines
- Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects
- FIREWORKS: a bottom-up approach to integrative coessentiality network analysis
- A genome-wide atlas of co-essential modules assigns function to uncharacterized genes
- Interpretation of cancer mutations using a multiscale map of protein systems