🧬 Project Overview

Welcome to the code repository for our paper:

📄 Alternative Splicing Decouples Local from Global PRC2 Activity

This repository houses the code used to generate the figures presented in the paper. The code is organized into R quarto notebooks, with each notebook dedicated to one of the seven main (and supplementary) figures in the paper.

Tip

For easy access to each analysis report, visit our main homepage with direct links to the analysis reports: 🔗 Main Homepage

Feel free to explore the code and reproduce our findings! 🌟

If you use our work, please cite us appropriately.

📖 Citation

Molecular Cell

Arecco N.^†@ , Mocavini I.^†, Blanco E., Ballaré C., Libman E., Bonnal S., Irimia M.^§@ & Di Croce L.^§@ February 12, 2024 (2024). Alternative Splicing Decouples Local from Global PRC2 Activity Mol Cell. DOI: 10.1016/j.molcel.2024.02.011 PMID: 38452766 ^†Co-first; ^§Co-last; ^@ Correspondance

BioRχiv

Arecco N.^†@, Mocavini I.^†, Blanco E., Ballaré C., Bonnal S., Irimia M.^§@, & Di Croce L.^§@ (2023). Alternative Splicing Decouples Local from Global PRC2 Activity BioRχiv. DOI: 10.1101/2023.04.30.538846 ^†Co-first; ^§Co-last; ^@Correspondance

Related links

• 🐦 BioRχiv twitter thread
• 🐦 Mol Cell twitter meme
• 🧠 Alternative splicing database
• 💡 ChIP-seq and RNA-seq fastq files (NCBI GEO)
• 💪 Mass spectrometry raw files (PRIDE: PXD046640, PXD046660, PXD046742)
• 🏗 Colabfold PRC2 structural predictions (GitHub repo)
• 🔬Immunofluorescence microscopy czi files (Mendeley data)