diff --git a/packages/react-dom-bindings/src/client/ReactFiberConfigDOM.js b/packages/react-dom-bindings/src/client/ReactFiberConfigDOM.js
index fb3e1abb4d5..f914752df06 100644
--- a/packages/react-dom-bindings/src/client/ReactFiberConfigDOM.js
+++ b/packages/react-dom-bindings/src/client/ReactFiberConfigDOM.js
@@ -3262,9 +3262,9 @@ function blurActiveElementWithinFragment(
     return false;
   }
   const instance = getInstanceFromHostFiber<Instance>(child);
-  if (instance === activeElement) {
+  if (instance === activeElement || instance.contains(activeElement)) {
     // $FlowFixMe[prop-missing]
-    instance.blur();
+    activeElement.blur();
     return true;
   }
   return false;
diff --git a/packages/react-dom/src/__tests__/ReactDOMFragmentRefs-test.js b/packages/react-dom/src/__tests__/ReactDOMFragmentRefs-test.js
index 628ebc85bf7..5c55ceffafe 100644
--- a/packages/react-dom/src/__tests__/ReactDOMFragmentRefs-test.js
+++ b/packages/react-dom/src/__tests__/ReactDOMFragmentRefs-test.js
@@ -454,6 +454,36 @@ describe('FragmentRefs', () => {
         expect(document.activeElement).toEqual(document.body);
       });
 
+      // @gate enableFragmentRefs
+      it('removes focus from a nested element inside of the Fragment', async () => {
+        const fragmentRef = React.createRef();
+        const root = ReactDOMClient.createRoot(container);
+
+        function Test() {
+          return (
+            <Fragment ref={fragmentRef}>
+              <div>
+                <input id="nested-input" />
+              </div>
+            </Fragment>
+          );
+        }
+
+        await act(() => {
+          root.render(<Test />);
+        });
+
+        await act(() => {
+          fragmentRef.current.focus();
+        });
+        expect(document.activeElement.id).toEqual('nested-input');
+
+        await act(() => {
+          fragmentRef.current.blur();
+        });
+        expect(document.activeElement).toEqual(document.body);
+      });
+
       // @gate enableFragmentRefs
       it('does not remove focus from elements outside of the Fragment', async () => {
         const fragmentRefA = React.createRef();