diff --git a/packages/browser-rum/src/domain/deflate/deflateWorker.ts b/packages/browser-rum/src/domain/deflate/deflateWorker.ts
index 3b9ac21c1b..d8eac03b1f 100644
--- a/packages/browser-rum/src/domain/deflate/deflateWorker.ts
+++ b/packages/browser-rum/src/domain/deflate/deflateWorker.ts
@@ -43,7 +43,11 @@ type DeflateWorkerState =
 export type CreateDeflateWorker = typeof createDeflateWorker
 
 export function createDeflateWorker(configuration: RumConfiguration): DeflateWorker {
-  return new Worker(configuration.workerUrl || URL.createObjectURL(new Blob([__BUILD_ENV__WORKER_STRING__])))
+  return new Worker(
+    getWorkerTrustedTypePolicy().createScriptURL(
+      configuration.workerUrl || URL.createObjectURL(new Blob([__BUILD_ENV__WORKER_STRING__]))
+    )
+  )
 }
 
 let state: DeflateWorkerState = { status: DeflateWorkerStatus.Nil }
@@ -150,3 +154,25 @@ function onError(configuration: RumConfiguration, source: string, error: unknown
     })
   }
 }
+
+// Trusted Types are not yet in TypeScript lib
+interface WindowWithTrustedTypes {
+  trustedTypes?: {
+    createPolicy(name: string, policy: TrustedTypesPolicy): TrustedTypesPolicy
+  }
+}
+
+interface TrustedTypesPolicy {
+  createScriptURL(url: string): string
+}
+
+let workerTrustedTypePolicyCache: TrustedTypesPolicy | undefined
+function getWorkerTrustedTypePolicy(): TrustedTypesPolicy {
+  if (!workerTrustedTypePolicyCache) {
+    const trustedTypes = (window as WindowWithTrustedTypes).trustedTypes
+    workerTrustedTypePolicyCache = trustedTypes
+      ? trustedTypes.createPolicy('datadog-worker', { createScriptURL: (url) => url })
+      : { createScriptURL: (url) => url }
+  }
+  return workerTrustedTypePolicyCache
+}
diff --git a/test/e2e/lib/framework/serverApps/mock.ts b/test/e2e/lib/framework/serverApps/mock.ts
index 148f813600..d5742f3072 100644
--- a/test/e2e/lib/framework/serverApps/mock.ts
+++ b/test/e2e/lib/framework/serverApps/mock.ts
@@ -197,6 +197,21 @@ export function createMockServerApp(servers: Servers, setup: string, setupOption
     res.end()
   })
 
+  app.get('/trusted-types-csp', (_req, res) => {
+    res.header(
+      'Content-Security-Policy',
+      [
+        `connect-src ${servers.datadogHttpApi.origin} ${servers.base.origin} ${servers.crossOrigin.origin} https://quota.browser-intake-datadoghq.com`,
+        `script-src 'self' 'unsafe-inline' ${servers.crossOrigin.origin}`,
+        "worker-src blob: 'self'",
+        "require-trusted-types-for 'script'",
+        'trusted-types datadog-chunks datadog-worker',
+      ].join(';')
+    )
+    res.send(setup)
+    res.end()
+  })
+
   app.get(/datadog-(?<packageName>[a-z-]*)\.js/, (req, res) => {
     const { originalUrl, params } = req
 
diff --git a/test/e2e/scenario/transport.scenario.ts b/test/e2e/scenario/transport.scenario.ts
index afcde9d35f..1fa00fc6a5 100644
--- a/test/e2e/scenario/transport.scenario.ts
+++ b/test/e2e/scenario/transport.scenario.ts
@@ -100,5 +100,39 @@ test.describe('transport', () => {
           expect(cspDocLog, "'CSP doc' log").toBeTruthy()
         })
       })
+
+    createTest('workerUrl initialization parameter')
+      .withRum({ compressIntakeRequests: true, workerUrl: '/worker.js' })
+      .withBasePath('/no-blob-worker-csp')
+      .run(async ({ intakeRegistry, flushEvents }) => {
+        await flushEvents()
+        expect(intakeRegistry.rumRequests.length).toBeGreaterThan(0)
+      })
+
+    test.describe('Trusted Types CSP', () => {
+      createTest('supports Trusted Types CSP with compression worker')
+        .withRum({ compressIntakeRequests: true })
+        .withBasePath('/trusted-types-csp')
+        .run(async ({ flushEvents, intakeRegistry }) => {
+          await flushEvents()
+          expect(intakeRegistry.rumRequests.length).toBeGreaterThan(0)
+        })
+
+      createTest('supports Trusted Types CSP with workerUrl')
+        .withRum({ compressIntakeRequests: true, workerUrl: '/worker.js' })
+        .withBasePath('/trusted-types-csp')
+        .run(async ({ intakeRegistry, flushEvents }) => {
+          await flushEvents()
+          expect(intakeRegistry.rumRequests.length).toBeGreaterThan(0)
+        })
+
+      createTest('supports Trusted Types CSP with session replay chunk')
+        .withRum({ sessionReplaySampleRate: 100 })
+        .withBasePath('/trusted-types-csp')
+        .run(async ({ flushEvents, intakeRegistry }) => {
+          await flushEvents()
+          expect(intakeRegistry.rumRequests.length).toBeGreaterThan(0)
+        })
+    })
   })
 })
diff --git a/webpack.base.ts b/webpack.base.ts
index 611fafc352..0fe3d9a59d 100644
--- a/webpack.base.ts
+++ b/webpack.base.ts
@@ -32,6 +32,9 @@ export default ({
     path: path.resolve('./bundle'),
     chunkFormat: 'module',
     chunkLoading: 'import',
+    trustedTypes: {
+      policyName: 'datadog-chunks',
+    },
   },
   target: ['web', 'es2020'],
   devtool: false,